Anyone have any problems taking felodipine for hypertension? -

this is personal advice, not medical advice Recent findings have suggested that felodipine in combination with grapefruit juice can cause abnormal (toxic) effects. Grapefruit juice is found to have an inhibiting effect over cytochrome P450 3A4. As a result the bioavailability of the drug and area under the curve (AUC) increase, increasing the risk for abnormal side effects. Therefore, special caution must be taken when mixing grapefruit juice with Felodipine.